A simple, Accurate, precise method was developed for the simultaneous estimation of the Olanzapine and Samidorphan in Tablet dosage form. Chromatogram was run through Std zorbax eclipse xdb-c18(150 x 4.6 mm, 5m) Mobile phase containing Buffer Na2Hpo4: Acetonitrile taken in the ratio 70:30 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.01N Na2Hpo4 buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 226nm. Retention time of Olanzapine and Samidorphan were found to be 2.209 min and 3.196 min. %RSD of the Olanzapine and Samidorphan were and found to be 0.6 and 0.2 respectively. %Recovery was obtained as 99.79% and 99.60% for Olanzapine and Samidorphan respectively. LOD, LOQ values obtained from regression equations of Olanzapine and Samidorphan were 0.09, 0.28 µg/ml and 0.04, 0.13µg/ml respectively. Regression equation of Olanzapine is y =40559x + 8327, and y = 39599x + 4901 of Samidorphan. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries

A medical product contains a substance that is pharmacologically active and that substance is called the active ingredient (AI) or active pharmaceutical ingredient (API) any substance intended to be used in the manufacture of a medicinal product and that, when so used, becomes an active ingredient of the medicinal product. Formulation is the process in which different chemical substances, including the active ingredient and excipients are combined to produce a final medical product. Duloxetine was studied under various conditions of stress, and the acid degradants were identified by LC-MS based on the behaviour of duloxetine under stress conditions. Under basic, oxidative and photolytic conditions, the drug has been found to be stable

The current work details the creation of a new rapid, simple, sensitive, and reproducible RP-HPLC, HPTLC, UV Spectrophotometry method for the analysis of Ibuprofen. This approach has certain benefits in terms of its simplicity and sensitivity and is usable in routine analysis. An NSAID considered to be relatively safe is ibuprofen. Ibuprofen is available in several preparations at present. pharmaceutical dosage forms could be determined by a specific, linear, precise, accurate method as well as a system which was suitable for detecting carvedilol in bulk and pharmaceutical dosage forms

The occurrence of obesity and diabetes are the most common problems in human beings in nowadays. They are referred as twin epidemics of 21st century. These both conditions are interrelated and are illustrated by using the term "Diabesity. Generally, obesity is the major risk factors for the development of type 2 diabetes. It is necessary to know about various drugs which are used to treat both diabetes and obesity. This review mainly focusses on the describing individual classes of antidiabetic and anti-obesity drugs and certain newly approved drugs which shows the weight and glycemic control effects