Quinoxalines are becoming the attractive target of deeper research due to its inherent diverse properties. Literature study gives an idea about various synthetically derived Quinoxalines which constitute a rising biomedical class of lowmolecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory, antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents. In the present review, we are discussing about the cytotoxic potential of Quinoxaline derivatives discovered to date, thus providing a first reference index for researchers to identify the potential targets of their Quinoxalines derived collections, which could facilitate the development of new Quinoxaline based therapies.

The azaphenothiazines are the modified structure of phenothiazines, the various types of azaphenothiazines are having its unique biological importance. This review is focused on the documentation of various azaphenothiazines and its biological activity. Based on the additional nitrogen atoms in the phenothiazines, it is classified as monoazaphenothiazines, diazaphenothiazines, triazaphenothiazines and tetraazaphenothiazines. These are the azaphenothiazines having the many biological activities such as anticancer, antimicrobial, CNS activity, antiobesity, antioxidant, anti-inflammatory, antiemetic, cytotoxic activity etc., the azaphenothiazine analogs are having various biological important so that synthesis of further substitution with this azaphenothiazine analogs are having main task for the researchers

In addition to treating superficial and systemic fungal infections, fluconazole is a triazole antifungal. There are many side effects associated with the oral use of fluconazole. In order to reduce the dose of the drug and avoid side effects such as liver damage and kidney damage, this formulation is made in order to improve patient compliance and reduce the dosage of the drug. By using a polymer with different concentrations, such as Carbopol 945 & NaCMC, this research aimed to formulate & evaluate different formulations of a topical gel containing fluconazole. Penetration was enhanced with methanol. Physical appearance, pH-value, spreadability, and drug content were evaluated for formulated fluconazole topical gel. In terms of physical characteristics, the gel was well formulated. As the polymer concentration in formulations F3 (105.20%) & F6 (110.5%) is higher, they show good drug content. F4 (99.30%) had the highest yield. Polymer concentration decreases the spreadability of gel. In order to prevent the risk of skin irritation, the formulation had a pH of 6-9