ABSTRACT The work submitted here is concerned with the synthesis and characterization of new [P,S]-chelate complexes of the iron supported by trimethylphosphine ligands and with an investigation of chemical responses of these systems. Among the new compounds of these metal is stable hydrido and methyl metal compounds in low oxidation states which are of particular interest as models for homogeneous catalysis.(3-Diphenylphosphanyl)- 2-thionaphthol (P^nSH)2 react with Fe (PMe3)4 to form monochelate Iron hydride FeH (P^nS) (PMe3)3 (1) or FeH CO (P^nS) (PMe3)2 (2), affords When 1 react with iodomethane to form monochelate Fe I (P^nS) (PMe3)3 (3), respectively, and (P^nS)2Fe(P^nS)2(4).Crystal and molecular structures are given for 1-4, and dynamic solution spectra are discussed. Keywords: Synthesis, Characterization, Chelate complex, Phosphine ligands, Dynamic spectra.

ABSTRACT Several methods are available for the preparation of 4-functionalized pyrazole derivatives and have been well documented in the literature. As a part of drug discovery program, the 1-phenyl-3-(1,3-diphenyl-h-pyrazol-4-yl)prop-2-en-1-one derivatives were synthezied from 4-formyl pyrazole with corresponding substituted acetophenones. A mild and simple three steps approach for the preparation of 1-phenyl-3-(1,3-diphenyl-1H-pyrazol-4-yl)prop-2-en-1-one derivatives, was employed using a wide range of substituted acetophenones that contain hydroxyl, halogens, methyl, methoxy, nitro and amino groups as substituents. 4-amino derivative (7), 3-methoxy,4-hydroxy derivative (11) and 3,4-dimethoxy derivative (12) exhibited marked antiinflammatory activities. These compounds also exhibited good antioxidant activities such as inhibition of DPPH, nitric oxide, superoxide radical, lipid peroxidation and reducing power ability. Many sterically held up compounds exhibited appreciable antiinflammatory and also antioxidant activities. Thus the antioxidant potential of these compounds may contribute to the anti-inflammatory activity. Keywords: DPPH, Acetophenone, Nitric acid, Lipid peroxidation.

ABSTRACTA large number of drugs and biologically relevant molecules contain heterocyclic systems. The presence of heteroatoms or groups imparts preferential specificities in their biological responses. Amongst the heterocyclic systems, thiazolidineis a biologically important scaffold. Thiazolidinones are the derivatives of thiazolidine which belong to an important group ofheterocyclic compounds. Thiazolidines are heterocyclic aromatic organic compounds with 5 membered saturated ring with athioether group and an amine group in 1 and 3 positions respectively. It is a sulfur analogue of Oxazolidine.Keywords: Thiazolidinone, Heterocyclic system.

ABSTRACT Adsorption is the attachment of atoms, ions, or molecules from a gas, liquid, or dissolved solid to a surface. This process creates a film of the adsorbate on the surface of the adsorbent. This process differs from absorption. Adsorption is a surface-based process while absorption involves the whole volume of the material. The term sorption means both processes, while desorption is the opposite of it. Adsorption is a surface phenomenon. It occurs or exists in natural, physical, biological, and chemical systems, and is widely used in industrial applications such as activated charcoal, capturing and using waste heat to provide cold water for air conditioning and other process requirements (adsorption chillers), synthetic resins, increase storage capacity of carbide-derived carbons, and water purification. Through this article we reviewed and threw some light on various basic aspects and prospects of adsorption phenomenon which occurring and dealing with chemical or medical sciences. In addition to this it also includes various applications which provide fruitful results in the field of pharmaceuticals and environmental related studies. Keywords: Adsorption theory, characteristics of adsorption, types of adsorptions, chemisorptions, physisorption, adsorption isotherm, application of adsorption.

The paper deals with short review and the determination of three trace metals namely. Cu, Fe, Mn, in the groundwater of different sites of Seepat, Bilaspur district of C.G. All activities carried out on the ground surface have direct orindirect impact on the ground water whether associated with urban, industrial or agricultural activities large scale concentratedsource of pollutants, such as industrial discharges and sub surface Injection of chemicals and hazardous are obvious source ofground water pollutants. This study was carryout in the Month of during April and May 2014. The samples were collectedfrom five different source of Bilaspur district of seepat villages. The results obtained are compared with safe limits in ppm forheavy metals laid down by BIS, WHO, ICMR, APHA.

Nowadays, Heterocyclic compounds are proving successful compounds in the field of medicinal chemistry tosynthesize various therapeutic compounds. There are enormous biological products developing and present having lots of anddifferent types of pharmacological compounds like anticonvulsants, antimicrobials etc. This study is showing the facts aboutthe synthesis of a heterocyclic compound or combination of such compounds exhibiting pharmacological properties bypyrimidine hydrazones. As we know that pyrimidine nucleus itself having efficiency and potency to exert pharmacologicalresponse as it is necessary and important to produce more and more of its variety. Pyrimidines are 6-membered heterocyclicring compounds composed of nitrogen and carbon. They are present throughout nature in various forms and are the buildingblocks of numerous natural compounds from antibiotics to vitamins and lipopolysaccharides.

Acids and bases are common solutions that exist everywhere. Almost every liquid that we see in our daily lifeconsists of acidic and basic properties, with the exception of water. They are differ in their properties and are able to neutralizeto form H2O, which will be discussed later in a subsection. The acids and bases can be classified by three major sections i.e.The Arrhenius definition which states that an acid produces H+ in solution and a base produces OH-, Later, Bronsted-Lowrywho said that acids have an ability to donate protons whereas the bases to accept the protons and thirdly, the Lewis definitionsof acids and bases which describes the acid and base as electron acceptor and donor respectively. This review article isthrowing light on some important as well as basic aspects of acids and bases including their physical and chemical properties.In addition to this, the study also investigated about the acid and base for their color tests on the litmus paper as identifications,including their ranges as per pH scale

A simple, precise, specific and accurate reverse phase high performance liquid chromatography (RP-HPLC) methoddevelopment and validation for the simultaneous estimation of Montelukast sodium and Fexofenadine HCl in pharmaceuticaltablet dosage form. The different analytical performance parameters such as linearity, accuracy, precision, specificity, LODand LOQ were determined according to ICH guidelines. RP-HPLC was conducted on Hypersil BDS C18 (250 mm length x4.6 mm ID, 5μm) column. The mobile phase was consisting of mixed phosphate buffer pH-3 and Acetonitrile in the ratio(20:80% v/v) and the flow rate was 1ml/min. Montelukast sodium and Fexofenadine HCl were monitored using ShimadzuProminence (Spinchrom ModuleLC-20AT) with auto sampling injector and UV detector. Linearity was observed inconcentration ranges of 0.4-2.4 μg/ ml and 4.8-28.8 μg/ ml for Montelukast sodium and Fexofenadine HCl respectively.Regression equation of Montelukast sodium is y=42.98x+6.536, and of Fexofenadine HCl is Y = 5.859+11.58, Correlationcoefficient was found to be 0.999, 0.999 for Montelukast sodium and Fexofenadine HCl respectively. The % recovery wasfound to be 99.74% for Montelukast sodium, 100.09% for Fexofenadine HCl. LOD value of Fexofenadine HCl andmontelukast sodium was found to be 0.13, 0.026, respectively. LOQ value of Fexofenadine HCl and Montelukast sodium wasfound to be 0.397, 0.081 respectively.

Data Mining, popularly known as Knowledge Discovery in databases (KDD) is the automated extraction of patternsrepresenting knowledge implicitly stored in large databases. Data sets grow in size in part because they are increasingly beinggathered by cheap and numerous information-sensing mobile devices, aerial (remote sensing), software logs, cameras,microphones, radio-frequency identification (RFID) readers, and wireless sensor networks. The World Wide Web as a GlobalInformation System has flooded us with a tremendous amount of data and information. This explosive growth in stored datahas generated an urgent need for new technologies and automated tools to assist us in transforming the data into usefulinformation and knowledge. Data mining process helps to extract information from a data set and transform it into anunderstandable structure. Two common data mining techniques for finding hidden patterns in data are clustering andclassification analyses. Clustering is an automated process to group related records together. Classification is similar toclustering in that it also segments customer records into distinct segments called classes. This paper provides survey onvarious clustering techniques and their role in Data mining.