Chemical modifications of drug molecules of a series having optimal activity is widely used and continue to be animportant factor in new drug discovery studies. In order to obtain new, effective and safe drugs has led today’s researchers toimprove the existing drugs by increasing their potency, duration of action and by decreasing the toxic side effects. Structureactivity studies show that variations in ring system or minor group extend distinct pharmacological effect upon the drugmolecules. 1,3,4-Thiadiazoles are biologically important group of compounds having activities like antibacterial, antifungal,antiinflammatory, diuretic, antiulcer, antihelmintic other biological activities. Prompted by these reports, it was contemplatedto synthesize new 1,3,4-thiadiazoles. Thus an attempt was made to synthesize 2-(5-{[(1Z)-substituted methylene]amino}-1,3,4-thiadiazol-2-yl)phenol derivatives in this present study . It is likely that the new derivatives with some modification intheir chemical structure may result in some profound change in the pharmacological response. It may increase, decrease oralter the nature of the response

This article depicts the isolation of Chrysin (1), which is a significant constituent from hexanes concentrate of Derris scandens. A progression of new 1,2,3-triazole subsidiaries of Chrysin were planned, combined and assessed for their anti-viral movement against NDV and BTV cell lines. These synthetic derivatives have indicated great anti-viral action. All of them (3a to 3g) were distinguished by using Nuclear Magnetic Resonance (NMR) and Mass spectroscopic techniques. Among derivatives, 3a, 3e, 3f and 3g displayed conspicuous action against NDV, then again 3a, 3b, 3c, 3e, 3f and 3g showed remarkable action against BTV than Chrysin.

Spectrochemical analysis, methods of chemical analysis that depends upon measurement of the wavelength and the intensity of electromagnetic radiation. Its major use is in the determination of the arrangement of atoms and electrons in molecules of chemical compounds based on the amounts of energy absorbed during changes in the structure or motion of the molecules. In its restricted and more common usage two methods usually are implied. The calibration curve was constructed by taking concentration on the X-axis and absorbance / area on the Y-axis. The linearity was evaluated by linear regression analysis. This was calculated by the least square regression method. The correlation coefficient and Y-intercept of the calibration curve were calculated

Imidazole is a five membered heterocyclic aromatic organic compound it is further classified as an alkaloid Imidazole refers to the parent compound C3H4N2, whereas imidazoles are a class of heterocycles with similar ring structure but varying substituents. This ring system is present in important biological building blocks such as histidine and the related hormone histamine. Imidazole can act as a base and as a week acid. Imidazole exists in two tautomeric forms with the hydrogen atom moving between the two nitrogen's. Many drugs contain an imidazole ring, such as antifungal drugs and nitro imidazole

A simple, accurate, precise and specific spectrophotometric method has been developed for simultaneous
determination of racecadotril and ofloxacin in its combined tablet dosage form by using methanol as a solvent. The method
involves absorbance correction based on measurement of absorbance at two wavelengths at 231 nm and 323.40 nm. Method
follows Beer’s linearity in the range of 10-24 μg/ml for racecadotril and 20-48 μg/ml ofloxacin both. The mean % recoveries
were found to be in the range of 99.22 – 100.66 % and 99.62 100.19 % for racecadotril and ofloxacin respectively. LOD and
LOQ were found to be 0.1922μg/ml and 0.5826 μg/ml for racecadotril and 0.1063 μg/ml and 0.3223 μg/ml for ofloxacin
respectively. Assay results of market formulation were found to be 99.24 % and 99.25 % for racecadotril and ofloxacin
respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of
racecadotril and ofloxacin in their combined Tablet dosage form

Current study was successfully completed with ideal for routine binary separation . The run time of study carried out with 3.8 minutes & injection volume is 20 µl. The detector used for optimization is silicon PDA and detection wavelength used for this method was 252. Elution technique carried out in the column when the temperature maintained up to 30 + 5 °C.Buffer was prepared with using 2.72 g Potassium dihydrogen orthophosphate and adjust the pH at 3.0 with OPA.Mobile Phase (Buffer: Acetonitrile- 600: 400). Methanol & Mobile Phase used as diluents.