Medicinal plants are of great importance to researchers in the field of pharmacology, as most pharmaceutical industries rely on medicinal plants as raw materials. Argyreia imbricata belongs to the family Convolvulaceae and is known for its medicinal properties. The present study was carried out to evaluate the antioxidant activity and possible bioactive components in the methanolic fraction of Argyreia imbricata. Phytochemical analysis of methanolic methanol fraction of Argyreia imbricata plant revealed the presence of flavonoids, tannins, phenols, saponins, alkaloids, glycosides, terpenoids and steroids. The GCMS analysis revealed the presence of 13 bioactive compounds, including eicosanoic acid, lauroyl peroxide, octadecanoic acid, 2-oxo, methyl ester, spiro[androst-5-en-17,1'-cyclobutan]-2'-one, pseduosarsasapogenin-5,20-diene. Phytochemical and GCMS profiling of the methanolic methanol fraction of the plant Argyreia imbricata revealed the presence of bioactive compounds with important medicinal properties. Therefore, the presence of these phytochemicals could be responsible for the therapeutic effect of the plant

This review emphasizes the significance of pyridine derivatives in the realm of pharmacology, focusing on their wide range of applications in drug discovery and development. We develop into the distinctive structural characteristics of pyridine derivatives that contribute to their pharmacological properties. Furthermore, we examine their therapeutic possibilities across diverse disease areas such as cancer, infectious diseases, neurological disorders, and cardiovascular conditions. By comprehending the importance of pyridine derivatives in pharmacology, researchers can effectively exploit their potential for creating and synthesizing innovative therapeutic agents

Phytochemicals, bioactive compounds present in various plant-based foods and botanical supplements, offer a wide range of potential health benefits to humans. However, their consumption also raises concerns regarding safety and potential toxicity. This comprehensive review delves into the intricate interplay between phytochemicals and human health, focusing on the evaluation of risks and benefits associated with their consumption. The review begins by providing an overview of phytochemicals, highlighting their prevalence in diets and their significance in promoting wellness. It explores the mechanisms underlying phytochemical metabolism and absorption, shedding light on factors influencing their bioavailability. While many phytochemicals exhibit protective effects through antioxidant and anti-inflammatory mechanisms, the article also investigates instances where these compounds can exert toxicity, unveiling the intricate pathways through which adverse effects may arise. Through the examination of notable case studies, such as the consumption of cyanogenic glycosides and alkaloids, the review underscores the importance of understanding threshold levels and the potential dangers of excessive consumption. Regulatory measures and guidelines for safe phytochemical consumption are explored, with a focus on the establishment of maximum tolerable intake levels to safeguard public health. Furthermore, the article navigates through the safety considerations associated with specific phytochemical classes, including flavonoids and terpenoids, providing insights into how to strike a balance between the beneficial effects and potential risks. The intricate interactions between phytochemicals and pharmaceuticals are also elucidated, emphasizing the importance of awareness and caution when combining herbal remedies with conventional medications. The abstract concludes by discussing the crucial role of risk communication and consumer education in fostering informed dietary choices. As the field of phytochemical research advances, this review examines the future directions of safety assessment, including advanced analytical techniques and personalized nutrition approaches. In essence, this review equips health practitioners, researchers, and consumers with a comprehensive understanding of the complexities surrounding phytochemical safety and toxicity, guiding them in navigating the dynamic landscape of plant-based compounds for human consumption

Some novel Pyrazoline derivatives have been synthesized by the condensation of isatin/5-chloroisatin with thiosemicarbazide to yield thiosemicarbazones, which were then cyclized to form corresponding thia-3, 4, 9-triaza-fluoren-2-ylamines. These were reacted with substituted aldehydes to give corresponding Schiff bases, which were cyclized using thioglycolic acid in the presence of zinc chloride to obtain the Pyrazoline derivatives. All the synthesized compounds were characterized by spectral (IR, MS and NMR) and elemental analysis. The compounds were screened for their antibacterial activity against Grampositive bacteria (B. subtilis, S. aureus, B. pumilus and M. luteus), Gram-negative bacteria (P. aeruginosa, E. coli and P. fluorescens) and for antifungal activity against A. niger and P. chrysogenum by agar-diffusion method. The minimum inhibitory concentrations of these compounds were also determined by tube dilution method. The antimicrobial effectiveness of all the compounds was found to be concentration dependent. Two compounds—2- methyl-3-(1-thia-3, 4, 9-triaza-fluoren-2- yl)-thiazolidin-4- one (7aI) and 2-naphthalen-1-yl-3-(1-thia-3, 4, 9-tri aza-fluoren-2-yl)-thiazolidin-4-one (7aII)—exhibited good antibacterial activity. The antibacterial activity of all the compounds was found to be better than the antifungal activity

Hydrotropy is a solubilization process whereby addition of a large amount of second solute results in an increase in the aqueous solubility of another solute. Hydrotropic agents are ionic organic salts. Additives or salts that increase the solubility in a given solvent are said to salt in the solute and those salts that decrease the solubility are said to “salt out” the solute. Perampanel is an orally active, non-competitive, and selective alpha- amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid glutamate receptor antagonist, with anti-epileptic activity. In UV spectroscopy the scan range was set between 200-400nm to obtain the maximum absorption by the compound. The wavelength at which Perampanel showed maximum absorbance was found to be 286.4nm. The UV absorption spectrum of Perampanel. The developed method has been validated according to ICH guidelines for linearity, range, precision (repeatability), accuracy, robustness, LOD and LOQ parameters. The results showed that the developed method is simple, precise, accurate and robust. Therefore, the method can be applied for routine analysis of Perampanel in bulk and pharmaceutical formulation.