In the present work mainly focused on the approach of the development of stability-indicating assay method for determination of Rivaroxaban in tablet formulation. The RP-HPLC separation was carried out on Agilent HPLC 1200 series, Waters HPLC with Empower software waters 2996 PDA, 2487, waters 2695 separation module PDA were used for quantitative estimation of Rivaroxaban in pharmaceutical dosage form using a Purospher star RP18 end-capped, 5? Hiber (250×4.6mm) with mobile phase comprising water: acetonitrile (60:40 v/v)+0.1 % TEA at flow rate of 1.0mL/min and UV detection at 280.0 nm. The method was validated as per ICH guidelines for accuracy, precision, specificity, linearity and range, ruggedness and robustness. The linearity of the proposed method was investigated in the range of 5% to 200% of the target concentration; the correlation coefficient for Rivaroxaban was found to be 0.999 which indicates the linear relationship between detector response and concentration. The proposed method was found to be simple, specific, linear and rugged and can be used for routine quality control

Anthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs. However, the in vivo anti-inflammatory activity and molecular mechanisms of anthraquinones have not been fully elucidated. We investigated the activity of anthraquinones using nociceptive experimental conditions. 1, 5 Dihydroxy Anthraquinone one of the major anthraquinones ameliorated various inflammatory acetic acid-induced abdominal writhing without displaying toxic profiles in body and organ weight, gastric irritation, or serum parameters. Our data strongly suggest that anthraquinones act as potent anti-inflammatory and antinociceptive components in vivo, thus contributing to the immune regulatory role of fruits and herbs